The Studio/CS11 editor saves on changes. Some browser plugins for search/replace (feature missing in Studio/CS11) or spell checkers do change the text but doesn't kick Studio into believing the text has changed. Unless the user manually inserts/removes a character changes made by those tools will be lost.
But at least for the spell checker Tansa (tansa.com) there is now a solution. Not sure it is official but we have it in production as of this morning so check with Tansa if you need it.
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